3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-rel-

Name	Golgicide A
Synonyms	GOLGICIDEA Golgicide A 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline rel-(3aR,9bS)-6,8-Difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-rel-
CAS	1139889-93-2

Molecular Formula	C17H14F2N2
Molar Mass	284.3
Appearance	Off-white solid
Storage Condition	Store at RT
In vitro study	Golgi IDE A inhibits the effect of Shiga toxin on protein synthesis with an IC50 of 3.3 μm. Golgi IDE A causes A decrease in gbf1-mediated Arf1 activation, blocks soluble secretions and membrane-anchored proteins, and subsequently impairs degenerated toxin transport. In J6/JFH1 cells, Golgi IDE A caused NS5A redistribution and accumulation of Transmissibility Virus particles.

biological activity	Golgi IDE A is A potent, rapidly reversible GBF1 inhibitor.
in vitro study	Golgi IDE A inhibits the effects of Shiga toxin on protein synthesis with an IC50 of 3.3 μm. Golgi IDE A causes A decrease in gbf1-mediated Arf1 activation, blocks soluble secretions and membrane-anchored proteins, and subsequently impairs degenerated toxin transport. In J6/JFH1 cells, Golgi IDE A caused NS5A redistribution and accumulation of Transmissibility Virus particles.
Target	GBF1

Last Update：2024-04-09 20:49:11

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CAS: 1139889-93-2
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Mobile: 18021002903
QQ: 3008007409

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3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-rel- Request for Quotation